EK LADKI KO DEKHA TOH AISA LAGA is the story of a girl wanting to love but is not allowed to due to societal pressures. Sweety (Sonam Kapoor Ahuja) lives in Moga, Punjab and is the daughter of Balbir Singh Chaudhury (Anil Kapoor), who runs a big garment factory. She completes her graduation and Balbir starts hunting for a suitable groom for her to marry. Sweety's authoritative brother Babloo (Abhishek Duhan) however realizes that Sweety secretly is in love with someone.
When she goes to Delhi to meet the lover, Babloo follows her. Sweety realizes and she runs away. She lands up in a drama auditorium where she bumps into play director Sahil Raza (Rajkummar Rao). Sweety ends up seeing the play rehearsal and remarks that the play lacks soul, as if the writer-director has never fallen in love. Sahil falls for her at that very instant.
Babloo however lands up at the theatre and Sahil helps her in running away from him. So smitten is Sahil by Sweety that he lands up in Moga. He pretends to conduct an acting workshop there and he's helped in his 'mission' by the lovable Chatro (Juhi Chawla). Babloo meanwhile tells Balbir and Beeji (Madhumalti Kapoor) that Sweety loves Sahil, a Muslim boy. Balbir is shocked and decides to immediately find a suitable match for Sweety.
Meanwhile, Sahil finds out from the house help in Chaudhury's Kothi, Chaubey (Brijendra Kala), that Sweety's family knows about him and that Sahil is here for his 'girlfriend' Sweety. Sahil's joy knows no bounds as he presumes that even Sweety likes him. On Beeji's grand birthday bash, Sahil meets Sweety in private and professes his love. This is when Sweety admits to him that she doesn't love him and that her love interest is a girl. What happens next forms the rest of the film.